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KMID : 0371319950480020189
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Journal of the Korean Surgical Society
1995 Volume.48 No. 2 p.189 ~ p.198
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Expression of c-erbB-2 Protein in Human Gasttic Cancer Cells
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Abstract
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C-erbB-2 is one of the most well known oncogenes in human malignant tumors and it is expressed about 8~20% in gastric carcinoma. But there is still controversy about the correlation between the c-erbB-2 overexpression and the prognosis of the
gastric
carcinoma.
So we studied the prognostic value of the c-erbB-2 overexpression by comparing the c-erbB-2 overexpression and known prognostic factors of the gastric carcinoma.
With single cell suspensions of normal gastric mucosa, primary gastric cancer tissues and malignant ells from asites arised from gastric carcinomas, the immunoreactivity to c-erbB-2 protein was examined.
@ES The results were as follows;
@EN 1) The c-erbB-2 protein was expressed only in cancer cells not in cells from normal mucosa. The expression frequency is significantly higher in metastatc tissues(malignant ascites)than those of primay sites.
2) The c-erbB-2 expression discrepancy between differentiated carcinomas and poorly differentiated carcinomas was not significant but these were significantly higher than that in signet ring cell carcinomas.
3) The c-erbB-2 expression frequency was significantly higher I serosal invasive carcinomas than that in serosal non-invasive carcinomas.
4) The c-erbB-2 expression frequency was significantly higher in tumor sizes of larger than 3 cm in diameter than that of less than 3 cm.
5) There were no statistically significant difcrepancy along with the lymph node metastasis and stages, but the more lymph nodes metastasis and the higher stages, the more c-erbB-2 expression was noted.
These results suggest that the c-erbB-2 overexpression is associated with aggressive cancer biologi behavior.
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